Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea
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 PubChem ID
CID: 156422
SID: 14885325
Canonical SMILES
Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C
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Compound Formula C31H37N5O3
Compound Structure
Protein Name
 Protein Info 
Mitogen-activated protein kinase 14
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
CMGC protein kinase group
>
CMGC protein kinase MAPK family
>
CMGC protein kinase p38 subfamily
Uniprot ID
Q16539
Gene Name
MAPK14
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 7.7 nM
   TI
   LI
   LO
   TS
CL000293 HLF
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 47 nM
   TI
   LI
   LO
   TS
CL000012 Sf21
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
Kd = 0.123 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.1 nM
2 IC50 = 10 nM
3 IC50 = 12 nM
4 IC50 = 17 nM
5 IC50 = 20 nM
6 IC50 = 44 nM
7 IC50 = 89 nM
8 IC50 = 398.11 nM
9 Kd = 0.046 nM
10 Kd = 0.098 nM
11 Kd = 0.1 nM
12 Kd = 0.16 nM
13 Kd = 0.24 nM
14 Kd = 0.37 nM
15 Kd = 0.45 nM
16 Kd = 1 nM
17 Kd = 1.3 nM
18 Kd = 12 nM
19 Ki = 0.097 nM
20 Ki = 6.4 nM
21 Ki = 22 nM
22 Ki < 46 nM