Brief Information of the Compound and Protein
Compound Name
1-[4-[6,7-bis(cyclopentylmethoxy)quinolin-4-yl]oxy-3-fluorophenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)urea
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Canonical SMILES
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4cc(OCC5CCCC5)c(OCC5CCCC5)cc34)c(F)c2)no1
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Compound Formula C35H41FN4O5
Compound Structure
Protein Name
Receptor-type tyrosine-protein kinase FLT3
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase PDGFR family
Uniprot ID
P36888
Gene Name
FLT3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  3
1
IC50 = 27.9 nM
   TI
   LI
   LO
   TS
2
IC50 = 37.2 nM
   TI
   LI
   LO
   TS
3
IC50 = 38.9 nM
   TI
   LI
   LO
   TS