Brief Information of the Compound and Protein
Compound Name
 Compound Info 
3-(3-benzyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-4,5-dihydro-1H-pyrrolo[3,4-b]pyrrol-6-one
    Show/Hide
 PubChem ID
CID: 155804537
Canonical SMILES
O=C1NCc2c(c[nH]c12)-c1cnc2[nH]cc(Cc3ccccc3)c2c1
    Show/Hide
Compound Formula C20H16N4O
Compound Structure
Protein Name
 Protein Info 
Hepatocyte growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Met family
Uniprot ID
P08581
Gene Name
MET
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000281 NCI-H1993
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 21880 nM
   TI
   LI
   LO
   TS
CL000012 Sf21
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  2
1
IC50 = 660 nM
   TI
   LI
   LO
   TS
2
Kd = 5300 nM
   TI
   LI
   LO
   TS