Brief Information of the Compound and Protein
Compound Name
1-(4-[4-[4-(4-Methylpiperazin-1-yl)-6-[[5-(oxetan-3-yl)-1H-pyrazol-3-yl]amino]pyrimidin-2-yl]phenyl]piperidin-1-yl)prop-2-en-1-one
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Canonical SMILES
C=CC(=O)N1CCC(c2ccc(-c3nc(Nc4cc(C5COC5)[nH]n4)cc(N4CCN(C)CC4)n3)cc2)CC1
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Compound Formula C29H36N8O2
Compound Structure
Protein Name
Fibroblast growth factor receptor 3
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase FGFR family
Uniprot ID
P22607
Gene Name
FGFR3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  2
1
GI50 = 11 nM
   TI
   LI
   LO
   TS
2
GI50 = 63 nM
   TI
   LI
   LO
   TS