Brief Information of the Compound and Protein
Compound Name
N-[4-[(E)-2-[4-[(5-Methyl-1H-pyrazol-3-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl]ethenyl]bicyclo[2.2.2]octan-1-yl]prop-2-enamide
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Canonical SMILES
C=CC(=O)NC12CCC(/C=C/c3nc(Nc4cc(C)[nH]n4)cc(N4CCN(C)CC4)n3)(CC1)CC2
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Compound Formula C26H36N8O
Compound Structure
Protein Name
Fibroblast growth factor receptor 3
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase FGFR family
Uniprot ID
P22607
Gene Name
FGFR3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  2
1
GI50 = 40 nM
   TI
   LI
   LO
   TS
2
GI50 = 158 nM
   TI
   LI
   LO
   TS