Brief Information of the Compound and Protein
Compound Name
N-[2-(3-Hydroxy-3-methylbutyl)-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide
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PubChem ID
CID: 121364971
Canonical SMILES
CC(C)(O)CCn1cc2cc(NC(=O)c3cccc(n3)C(F)(F)F)c(cc2n1)C(C)(C)O
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Compound Formula C22H25F3N4O3
Compound Structure
Protein Name
Interleukin-1 receptor-associated kinase 4
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase IRAK family
Uniprot ID
Q9NWZ3
Gene Name
IRAK4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000040 THP-1 Homo sapiens (Human)  1
1
IC50 = 128 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 8.6 nM