Brief Information of the Compound and Protein
Compound Name
 Compound Info 
US10562853, Compound 51
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 PubChem ID
CID: 132257265
Canonical SMILES
CNc1ccccc1OCCNCC1(F)CCN(CC1)C(=O)c1ccc(F)c(Cl)c1
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Compound Formula C22H26ClF2N3O2
Compound Structure
Protein Name
 Protein Info 
5-hydroxytryptamine receptor 1A
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Serotonin receptor
Uniprot ID
P08908
Gene Name
HTR1A
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  4
1
EC50 = 1.38 nM
   TI
   LI
   LO
   TS
2
EC50 = 15.14 nM
   TI
   LI
   LO
   TS
3
EC50 = 102.33 nM
   TI
   LI
   LO
   TS
4
Ki = 0.1175 nM
   TI
   LI
   LO
   TS
CL000043 U2OS
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 162.18 nM
   TI
   LI
   LO
   TS