Brief Information of the Compound and Protein
Compound Name
 Compound Info 
8-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
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 PubChem ID
CID: 124087
SID: 14874264
Canonical SMILES
Clc1ccc2c(CCc3cccnc3C2=C2CCNCC2)c1
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Compound Formula C19H19ClN2
Compound Structure
Protein Name
 Protein Info 
Histamine H1 receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Histamine receptor
Uniprot ID
P35367
Gene Name
HRH1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
Kd = 24 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
Ki = 0.97 nM
   TI
   LI
   LO
   TS
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  1
1
Ki = 1.585 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 1.84 nM
2 IC50 = 16000 nM