Brief Information of the Compound and Protein
| Compound Name |
4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide
Show/Hide
|
PubChem ID | |||||
|
Compound Structure |
|
|||||
| Protein Name |
Mast/stem cell growth factor receptor Kit
|
Protein Classification |
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase PDGFR family
|
||||
| Uniprot ID | Gene Name | KIT |
|||||
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
| Cell Line ID | Cell Line Name | Cell Line Organism | |
| CL000012 | Sf21 | Spodoptera frugiperda (Fall armyworm) | 1 |
| 1 |
IC50 = 158 nM
|
TI
LI
LO
TS
|
|
|---|---|---|---|
Biochemical Assays
| 1 | IC50 < 10 nM | ||
|---|---|---|---|
| 2 | IC50 = 14.7 nM | ||
| 3 | IC50 = 158 nM | ||
| 4 | IC50 > 200 nM | ||
| 5 | IC50 > 1000 nM | ||
| 6 | Kd = 17 nM | ||
| 7 | Kd = 22 nM | ||
| 8 | Kd = 29 nM | ||
| 9 | Kd = 46 nM | ||
| 10 | Kd = 150 nM | ||
| 11 | Kd = 260 nM | ||
| 12 | Kd = 540 nM | ||
| 13 | Kd = 770 nM | ||