Brief Information of the Compound and Protein
Compound Name
1-(5-(tert-butyl)isoxazol-3-yl)-3-(4-(1-(4-(2-morpholinoethoxy)-2-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)phenyl)urea
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PubChem ID
CID: 156010335
Canonical SMILES
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn(-c4ccc(OCCN5CCOCC5)cc4C(F)(F)F)nn3)cc2)no1
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Compound Formula C29H32F3N7O4
Compound Structure
Protein Name
Receptor-type tyrosine-protein kinase FLT3
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase PDGFR family
Uniprot ID
P36888
Gene Name
FLT3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  1
1
GI50 = 40.5 nM
   TI
   LI
   LO
   TS
CL000091 MV4-11 Homo sapiens (Human)  1
1
GI50 = 58.6 nM
   TI
   LI
   LO
   TS