Bioactivity Information | MolBiC

Brief Information of the Compound and Protein

Compound Name

Compound Info

US10034864, Example 1

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PubChem ID

CID: 135564890

SID: 87458391

Canonical SMILES	NS(=O)(=O)NCCNc1nonc1C(Nc1ccc(F)c(Br)c1)=NO Show/Hide
Compound Formula	C11H13BrFN7O4S

Compound Structure

Protein Name

Protein Info

Indoleamine 2,3-dioxygenase 1

Protein Classification

Enzyme

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Oxidoreductase

Uniprot ID

P14902

Gene Name

IDO1

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000025	HEK-293T Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 9.63 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	2
1	EC50 = 8.74 nM	TI LI LO TS
2	IC50 = 12.6 nM	TI LI LO TS
CL000017	HeLa Cell Line Info	Homo sapiens (Human)	12
1	EC50 = 8 nM	TI LI LO TS
2	EC50 = 13 nM	TI LI LO TS
3	IC50 = 7 nM	TI LI LO TS
4	IC50 = 7.1 nM	TI LI LO TS
5	IC50 = 7.4 nM	TI LI LO TS
6	IC50 = 10 nM	TI LI LO TS
7	IC50 = 10.3 nM	TI LI LO TS
8	IC50 = 11 nM	TI LI LO TS
9	IC50 = 12.5 nM	TI LI LO TS
10	IC50 = 16 nM	TI LI LO TS
11	IC50 = 20 nM	TI LI LO TS
12	IC50 = 70 nM	TI LI LO TS
CL000040	THP-1 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 5.6 nM	TI LI LO TS

Biochemical Assays

1	IC50 = 10 nM
2	IC50 = 58 nM
3	IC50 = 64.6 nM
4	IC50 = 66 nM
5	IC50 = 71.8 nM
6	IC50 = 72 nM
7	IC50 = 73 nM
8	IC50 = 75 nM
9	IC50 = 77.8 nM
10	IC50 = 80 nM
11	IC50 = 87.4 nM
12	IC50 = 90 nM
13	IC50 = 91 nM
14	IC50 = 93 nM
15	IC50 = 125 nM