Brief Information of the Compound and Protein
Compound Name
 Compound Info 
3-(2-methoxyphenyl)-1'-prop-2-enylspiro[1H-quinazoline-2,3'-indole]-2',4-dione
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 PubChem ID
CID: 3634416
Canonical SMILES
COc1ccccc1N1C(=O)c2ccccc2NC11C(=O)N(CC=C)c2ccccc12
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Compound Formula C25H21N3O3
Compound Structure
Protein Name
 Protein Info 
Orexin/Hypocretin receptor type 1
Protein Classification
Membrane receptor
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Family A G protein-coupled receptor
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Peptide receptor (family A GPCR)
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Short peptide receptor (family A GPCR)
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Orexin receptor
Uniprot ID
O43613
Gene Name
HCRTR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  3
1
IC50 = 20900 nM
   TI
   LI
   LO
   TS
2
Ki = 12000 nM
   TI
   LI
   LO
   TS
3
Ki = 21600 nM
   TI
   LI
   LO
   TS