Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[4-(1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)phenyl]urea
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 PubChem ID
CID: 71575642
SID: 163619554
Canonical SMILES
FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ncnc4n[nH]cc34)cc2)ccc1Cl
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Compound Formula C19H12ClF3N6O2
Compound Structure
Protein Name
 Protein Info 
Receptor-type tyrosine-protein kinase FLT3
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase PDGFR family
Uniprot ID
P36888
Gene Name
FLT3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000091 MV4-11
 Cell Line Info 
Homo sapiens (Human)  3
1
IC50 = 1 nM
   TI
   LI
   LO
   TS
2
IC50 = 3 nM
   TI
   LI
   LO
   TS
3
IC50 = 4 nM
   TI
   LI
   LO
   TS
CL000012 Sf21
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 39 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 4 nM
2 IC50 = 39 nM
3 Kd = 4.3 nM