Brief Information of the Compound and Protein
Compound Name
4-[(2-phenylquinazolin-4-yl)amino]benzonitrile
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PubChem ID
CID: 13168110
Canonical SMILES
N#Cc1ccc(Nc2nc(nc3ccccc23)-c2ccccc2)cc1
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Compound Formula C21H14N4
Compound Structure
Protein Name
Broad substrate specificity ATP-binding cassette transporter ABCG2
Protein Classification
Transporter
>
Primary active transporter
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ATP-binding cassette
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ABCG subfamily
Uniprot ID
Q9UNQ0
Gene Name
ABCG2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000036 MDCK-II Canis lupus familiaris (Dog)  6
1
EC50 = 41 nM
   TI
   LI
   LO
   TS
2
EC50 = 53 nM
   TI
   LI
   LO
   TS
3
GI50 = 4.41 nM
   TI
   LI
   LO
   TS
4
IC50 = 69.9 nM
   TI
   LI
   LO
   TS
5
IC50 = 71.4 nM
   TI
   LI
   LO
   TS
6
IC50 = 84.5 nM
   TI
   LI
   LO
   TS