Brief Information of the Compound and Protein
Compound Name
 Compound Info 
AP-26113
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 PubChem ID
CID: 68165256
Canonical SMILES
COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1)N1CCC(CC1)N1CCN(C)CC1
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Compound Formula C29H39ClN7O2P
Compound Structure
Protein Name
 Protein Info 
Epidermal growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase EGFR family
Uniprot ID
P00533
Gene Name
EGFR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3
 Cell Line Info 
Mus musculus (Mouse)  1
1
GI50 = 67.2 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  3
1
IC50 = 1 nM
   TI
   LI
   LO
   TS
2
IC50 = 3 nM
   TI
   LI
   LO
   TS
3
IC50 = 130 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.7 nM
2 IC50 = 0.82 nM
3 IC50 = 1.5 nM
4 IC50 = 2.5 nM
5 IC50 = 3.38 nM
6 IC50 = 3.9 nM
7 IC50 = 4.9 nM
8 IC50 = 6.6 nM
9 IC50 = 10.5 nM
10 IC50 = 12.5 nM
11 IC50 = 17.2 nM
12 IC50 = 18.5 nM
13 IC50 = 21 nM
14 IC50 = 28.3 nM
15 IC50 = 37.6 nM
16 IC50 = 38.3 nM
17 IC50 = 48.3 nM
18 IC50 = 50.9 nM
19 IC50 = 53 nM
20 IC50 = 74.8 nM
21 IC50 = 76.6 nM
22 IC50 = 139.7 nM
23 IC50 = 261.3 nM