Brief Information of the Compound and Protein
| Compound Name |
IBRUTINIB
Show/Hide
|
PubChem ID | |||||
|
Compound Structure |
|
|||||
| Protein Name |
Tyrosine-protein kinase ITK/TSK
|
Protein Classification |
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Tec family
|
||||
| Uniprot ID | Gene Name | ITK |
|||||
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
| Cell Line ID | Cell Line Name | Cell Line Organism | |
| CL000001 | Jurkat | Homo sapiens (Human) | 1 |
| 1 |
IC50 = 76.9 nM
|
TI
LI
LO
TS
|
|
|---|---|---|---|
| CL000012 | Sf21 | Spodoptera frugiperda (Fall armyworm) | 1 |
| 1 |
IC50 = 5 nM
|
TI
LI
LO
TS
|
|
Biochemical Assays
| 1 | IC50 = 2.7 nM | ||
|---|---|---|---|
| 2 | IC50 = 3 nM | ||
| 3 | IC50 = 4.9 nM | ||
| 4 | IC50 = 10.7 nM | ||
| 5 | IC50 = 13.9 nM | ||
| 6 | IC50 = 33.7 nM | ||
| 7 | IC50 = 99 nM | ||
| 8 | Kd = 57 nM | ||
| 9 | Kd = 63 nM | ||