Brief Information of the Compound and Protein
Compound Name
 Compound Info 
US10005782, Compound 121
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Canonical SMILES
NC(=O)c1c(nn2c3CCN(CCc3[nH]c12)C(=O)C=C)-c1ccc(Oc2ccccc2)cc1
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Compound Formula C25H23N5O3
Compound Structure
Protein Name
 Protein Info 
Tyrosine-protein kinase BTK
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Tec family
Uniprot ID
Q06187
Gene Name
BTK
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000003 Ramos
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 8.2 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 0.36 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.36 nM