Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1H-indol-2-yl-[4-[2-(4-methoxyphenoxy)ethyl]piperazin-1-yl]methanone
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 PubChem ID
CID: 27842480
Canonical SMILES
COc1ccc(OCCN2CCN(CC2)C(=O)c2cc3ccccc3[nH]2)cc1
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Compound Formula C22H25N3O3
Compound Structure
Protein Name
 Protein Info 
D(3) dopamine receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Dopamine receptor
Uniprot ID
P35462
Gene Name
DRD3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  2
1
EC50 = 21 nM
   TI
   LI
   LO
   TS
2
EC50 = 38 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  12
1
EC50 = 0.18 nM
   TI
   LI
   LO
   TS
2
EC50 = 1.2 nM
   TI
   LI
   LO
   TS
3
EC50 = 17 nM
   TI
   LI
   LO
   TS
4
EC50 = 86 nM
   TI
   LI
   LO
   TS
5
EC50 = 520 nM
   TI
   LI
   LO
   TS
6
Ki = 12.5 nM
   TI
   LI
   LO
   TS
7
Ki = 22 nM
   TI
   LI
   LO
   TS
8
Ki = 94 nM
   TI
   LI
   LO
   TS
9
Ki = 350 nM
   TI
   LI
   LO
   TS
10
Ki = 720 nM
   TI
   LI
   LO
   TS
11
Ki = 1500 nM
   TI
   LI
   LO
   TS
12
Ki = 3700 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 1240 nM