Brief Information of the Compound and Protein
Compound Name
(2R)-N-[3-[2-[(2-fluoropyridin-3-yl)amino]-5-methylpyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propanamide
    Show/Hide
PubChem ID
CID: 155532106
Canonical SMILES
C[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccnc2F)ncc1C
    Show/Hide
Compound Formula C26H29FN8O
Compound Structure
Protein Name
Tyrosine-protein kinase JAK1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase JakB family
Uniprot ID
P23458
Gene Name
JAK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000157 NCI-H1975 Homo sapiens (Human)  1
1
IC50 = 80 nM
   TI
   LI
   LO
   TS