Brief Information of the Compound and Protein
Compound Name
 Compound Info 
US8569311, E-5
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 PubChem ID
CID: 25128145
SID: 56452417
Canonical SMILES
C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(C)ccc1-c1ncccn1
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Compound Formula C24H25FN4O2
Compound Structure
Protein Name
 Protein Info 
Orexin/Hypocretin receptor type 1
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
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Peptide receptor (family A GPCR)
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Short peptide receptor (family A GPCR)
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Orexin receptor
Uniprot ID
O43613
Gene Name
HCRTR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000012 Sf21
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
Ki = 0.631 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 16 nM
2 Ki = 2.2 nM
3 Ki = 2.5 nM
4 Ki = 2.9 nM