Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b
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 PubChem ID
CID: 5330790
SID: 12015752
Canonical SMILES
Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F
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Compound Formula C15H12F2N6O3S
Compound Structure
Protein Name
 Protein Info 
Tyrosine-protein kinase JAK2
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase JakB family
Uniprot ID
O60674
Gene Name
JAK2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000023 BTI-Tn-5B1-4
 Cell Line Info 
Trichoplusia ni (Cabbage looper)  1
1
Kd = 94 nM
   TI
   LI
   LO
   TS
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 2960 nM
   TI
   LI
   LO
   TS
2
IC50 = 11050 nM
   TI
   LI
   LO
   TS
CL000082 HEL
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 1 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  5
1
Kd = 456 nM
   TI
   LI
   LO
   TS
2
Kd = 460 nM
   TI
   LI
   LO
   TS
3
Kd = 490 nM
   TI
   LI
   LO
   TS
4
Kd = 600 nM
   TI
   LI
   LO
   TS
5
Kd = 670 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Kd = 220 nM
2 Kd = 800 nM