Brief Information of the Compound and Protein
Compound Name
3-[2-[5-methyl-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]-6,7-dihydro-4H-furo[3,2-c]pyridin-5-yl]-3-oxopropanenitrile
    Show/Hide
PubChem ID
CID: 72202547
Canonical SMILES
COc1cc(Nc2ncc(C)c(n2)-c2cc3CN(CCc3o2)C(=O)CC#N)cc(OC)c1OC
    Show/Hide
Compound Formula C24H25N5O5
Compound Structure
Protein Name
Tyrosine-protein kinase JAK3
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase JakB family
Uniprot ID
P52333
Gene Name
JAK3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000129 HT-2 Mus musculus (Mouse)  1
1
IC50 = 200.3 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 12 nM