Brief Information of the Compound and Protein
Compound Name
 Compound Info 
2-amino-9-[(1R,6R,8R,9R,10S,15R,17R,18R)-8-(6-aminopurin-9-yl)-3,9,12,18-tetrahydroxy-3,12-dioxo-2,4,7,11,13,16-hexaoxa-3lambda5,12lambda5-diphosphatricyclo[13.2.1.06,10]octadecan-17-yl]-1H-purin-6-one
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 PubChem ID
CID: 135564529
Canonical SMILES
Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@@H]2COP(O)(=O)O[C@@H]3[C@@H](COP(O)(=O)O[C@@H]1[C@@H]2O)O[C@H]([C@@H]3O)n1cnc2c(N)ncnc12
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Compound Formula C20H24N10O13P2
Compound Structure
Protein Name
 Protein Info 
Stimulator of interferon genes protein
Protein Classification
Unclassified protein
Uniprot ID
Q86WV6
Gene Name
STING1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  5
1
EC50 = 20 nM
   TI
   LI
   LO
   TS
2
EC50 = 40 nM
   TI
   LI
   LO
   TS
3
EC50 = 50 nM
   TI
   LI
   LO
   TS
4
EC50 = 13700 nM
   TI
   LI
   LO
   TS
5
EC50 = 28370 nM
   TI
   LI
   LO
   TS
CL000040 THP-1
 Cell Line Info 
Homo sapiens (Human)  3
1
EC50 = 7200 nM
   TI
   LI
   LO
   TS
2
EC50 = 38600 nM
   TI
   LI
   LO
   TS
3
EC50 = 39100 nM
   TI
   LI
   LO
   TS
CL000494 THP1-Dual
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 30100 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 5.8 nM
2 EC50 = 50 nM
3 EC50 = 19600 nM
4 IC50 = 1.8 nM
5 IC50 = 5.5 nM
6 Kd = 6.2 nM
7 Kd = 3790 nM
8 Kd = 42000 nM