Brief Information of the Compound and Protein
Compound Name
 Compound Info 
N-(2,2-dimethylpropyl)-4-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrimidin-2-amine;2,2,2-trifluoroacetic acid
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 PubChem ID
CID: 155516421
Canonical SMILES
OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CN[C@@H]1CCN(C1)c1ccnc(NCC(C)(C)C)n1
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Compound Formula C18H27F6N5O4
Compound Structure
Protein Name
 Protein Info 
Histamine H4 receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Histamine receptor
Uniprot ID
Q9H3N8
Gene Name
HRH4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000903 HEK293-SF-hH4R-His6-CRE-Luc
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 0.6026 nM
   TI
   LI
   LO
   TS
CL000912 HEK293T-beta-arr2-hH4R
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 6.918 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
Ki = 3.802 nM
   TI
   LI
   LO
   TS