Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-N-(3-aminopropyl)-2-N-(2,2-dimethylpropyl)pyrimidine-2,4-diamine;2,2,2-trifluoroacetic acid
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 PubChem ID
CID: 155512724
Canonical SMILES
OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CC(C)(C)CNc1nccc(NCCCN)n1
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Compound Formula C16H25F6N5O4
Compound Structure
Protein Name
 Protein Info 
Histamine H4 receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Histamine receptor
Uniprot ID
Q9H3N8
Gene Name
HRH4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000903 HEK293-SF-hH4R-His6-CRE-Luc
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 29.51 nM
   TI
   LI
   LO
   TS
CL000912 HEK293T-beta-arr2-hH4R
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 39.81 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
Ki = 36.31 nM
   TI
   LI
   LO
   TS