Brief Information of the Compound and Protein
Compound Name
4-(1,4-diazepan-1-yl)-N-(2,2-dimethylpropyl)pyrimidin-2-amine;2,2,2-trifluoroacetic acid
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PubChem ID
CID: 155541279
Canonical SMILES
OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CC(C)(C)CNc1nccc(n1)N1CCCNCC1
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Compound Formula C18H27F6N5O4
Compound Structure
Protein Name
Histamine H4 receptor
Protein Classification
Membrane receptor
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Family A G protein-coupled receptor
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Small molecule receptor (family A GPCR)
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Monoamine receptor
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Histamine receptor
Uniprot ID
Q91ZY1
Gene Name
HRH4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000956 HEK293-SF-rH4R-His6-CRE-Luc Homo sapiens (Human)  1
1
EC50 = 93.33 nM
   TI
   LI
   LO
   TS
CL000910 HEK293T-beta-arr2-rH4R Homo sapiens (Human)  1
1
EC50 = 645.65 nM
   TI
   LI
   LO
   TS