Brief Information of the Compound and Protein
Compound Name
(buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione
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PubChem ID
CID: 2477
SID: 14902734
Canonical SMILES
O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1
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Compound Formula C21H31N5O2
Compound Structure
Protein Name
D(2) dopamine receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
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Small molecule receptor (family A GPCR)
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Monoamine receptor
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Dopamine receptor
Uniprot ID
P14416
Gene Name
DRD2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 13 nM
   TI
   LI
   LO
   TS
CL000873 HEK-GIRK-M4 Homo sapiens (Human)  1
1
Ki = 484 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 13 nM
2 Ki = 90 nM
3 Ki = 1000 nM