Brief Information of the Compound and Protein
Compound Name
 Compound Info 
FORETINIB
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 PubChem ID
CID: 42642645
SID: 81082087
Canonical SMILES
COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
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Compound Formula C34H34F2N4O6
Compound Structure
Protein Name
 Protein Info 
Hepatocyte growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Met family
Uniprot ID
P08581
Gene Name
MET
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3
 Cell Line Info 
Mus musculus (Mouse)  1
1
IC50 = 9.2 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.4 nM
2 IC50 = 0.5 nM
3 IC50 = 1.1 nM
4 IC50 = 1.14 nM
5 IC50 = 1.16 nM
6 IC50 = 1.24 nM
7 IC50 = 1.41 nM
8 IC50 = 1.43 nM
9 IC50 = 1.48 nM
10 IC50 = 1.56 nM
11 IC50 = 1.63 nM
12 IC50 = 1.64 nM
13 IC50 = 1.65 nM
14 IC50 = 1.75 nM
15 IC50 = 1.76 nM
16 IC50 = 1.83 nM
17 IC50 = 1.84 nM
18 IC50 = 1.86 nM
19 IC50 = 1.92 nM
20 IC50 = 1.93 nM
21 IC50 = 2.05 nM
22 IC50 = 2.11 nM
23 IC50 = 2.15 nM
24 IC50 = 3.2 nM
25 IC50 = 4 nM
26 IC50 = 7.9 nM
27 IC50 = 14 nM
28 IC50 = 19 nM
29 Kd = 0.82 nM
30 Kd = 1 nM
31 Kd = 1.4 nM