Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(1S,2S,3R,4R)-3-[[5-cyano-2-[4-[4-(dimethylamino)piperidin-1-yl]-2-(2-methylpropoxy)anilino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide
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 PubChem ID
CID: 145980752
Canonical SMILES
CC(C)COc1cc(ccc1Nc1ncc(C#N)c(N[C@@H]2[C@@H]3C[C@@H](C=C3)[C@@H]2C(N)=O)n1)N1CCC(CC1)N(C)C
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Compound Formula C30H40N8O2
Compound Structure
Protein Name
 Protein Info 
Fibroblast growth factor receptor 4
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase FGFR family
Uniprot ID
P22455
Gene Name
FGFR4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3
 Cell Line Info 
Mus musculus (Mouse)  1
1
IC50 = 162 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  5
1
IC50 = 2.2 nM
   TI
   LI
   LO
   TS
2
IC50 = 6.9 nM
   TI
   LI
   LO
   TS
3
IC50 = 7.5 nM
   TI
   LI
   LO
   TS
4
IC50 = 8.4 nM
   TI
   LI
   LO
   TS
5
Kd = 20 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 2.2 nM