Brief Information of the Compound and Protein
Compound Name
1-[(4R)-4-[2-amino-5-(1-methylimidazol-4-yl)pyridin-3-yl]oxy-3,3-difluoropyrrolidin-1-yl]-2-[4-(trifluoromethoxy)phenyl]ethanone
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PubChem ID
CID: 145963881
Canonical SMILES
Cn1cnc(c1)-c1cnc(N)c(O[C@@H]2CN(CC2(F)F)C(=O)Cc2ccc(OC(F)(F)F)cc2)c1
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Compound Formula C22H20F5N5O3
Compound Structure
Protein Name
High affinity nerve growth factor receptor
Protein Classification
Enzyme
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Kinase
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Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Trk family
Uniprot ID
P04629
Gene Name
NTRK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000043 U2OS Homo sapiens (Human)  1
1
IC50 = 1800 nM
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