Brief Information of the Compound and Protein
Compound Name
 Compound Info 
2,2-difluoro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(6-methoxypyridin-3-yl)-3-methylbutan-2-yl]propanamide
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 PubChem ID
CID: 145964914
Canonical SMILES
COc1ccc(cn1)[C@@H](Oc1ccc2n(ncc2c1)-c1ccc(F)cc1)[C@@H](NC(=O)C(C)(F)F)C(C)C
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Compound Formula C27H27F3N4O3
Compound Structure
Protein Name
 Protein Info 
Glucocorticoid receptor
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 3
>
Nuclear hormone receptor subfamily 3 group C
>
Nuclear hormone receptor subfamily 3 group C member 1
Uniprot ID
P04150
Gene Name
NR3C1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000464 ChaGo-K-1
 Cell Line Info 
Homo sapiens (Human)  3
1
EC50 = 3.5 nM
   TI
   LI
   LO
   TS
2
IC50 = 0.57 nM
   TI
   LI
   LO
   TS
3
IC50 = 70 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 18 nM