Brief Information of the Compound and Protein
Compound Name
 Compound Info 
N-[(1R,2S,3S)-1-(3,5-difluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-3-hydroxybutan-2-yl]-5-methyl-1,3,4-oxadiazole-2-carboxamide
    Show/Hide
 PubChem ID
CID: 145974260
Canonical SMILES
C[C@H](O)[C@H](NC(=O)c1nnc(C)o1)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(F)cc1)c1cc(F)cc(F)c1
    Show/Hide
Compound Formula C27H22F3N5O4
Compound Structure
Protein Name
 Protein Info 
Glucocorticoid receptor
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 3
>
Nuclear hormone receptor subfamily 3 group C
>
Nuclear hormone receptor subfamily 3 group C member 1
Uniprot ID
P04150
Gene Name
NR3C1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000464 ChaGo-K-1
 Cell Line Info 
Homo sapiens (Human)  3
1
EC50 = 3.5 nM
   TI
   LI
   LO
   TS
2
IC50 = 1.6 nM
   TI
   LI
   LO
   TS
3
IC50 = 270 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 16 nM
2 IC50 = 180 nM