Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-(2-{[5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]amino}ethyl)phenol
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 PubChem ID
CID: 176407
SID: 14777778
Canonical SMILES
Nc1nc(NCCc2ccc(O)cc2)nc2nc(nn12)-c1ccco1
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Compound Formula C16H15N7O2
Compound Structure
Protein Name
 Protein Info 
Adenosine receptor A2b
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
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Nucleotide-like receptor (family A GPCR)
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Adenosine receptor
Uniprot ID
P29275
Gene Name
ADORA2B
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  4
1
IC50 = 48 nM
   TI
   LI
   LO
   TS
2
IC50 = 51 nM
   TI
   LI
   LO
   TS
3
IC50 = 94.9 nM
   TI
   LI
   LO
   TS
4
Ki = 42 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  2
1
Ki = 28 nM
   TI
   LI
   LO
   TS
2
Ki = 65.7 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Activity = 28 nM
2 Ki = 30 nM
3 Ki = 50 nM