Brief Information of the Compound and Protein
Compound Name
 Compound Info 
US8940748, 34
    Show/Hide
 PubChem ID
CID: 51039270
SID: 117699783
Canonical SMILES
CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
    Show/Hide
Compound Formula C17H17ClFN5O3S
Compound Structure
Protein Name
 Protein Info 
Beta-secretase 2
Protein Classification
Enzyme
>
Protease
>
Aspartic protease
>
Aspartic protease AA clan
>
Aspartic protease A1A subfamily
Uniprot ID
Q9Y5Z0
Gene Name
BACE2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 3.3 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Activity = 2.44 nM
2 IC50 = 4.5 nM
3 Ki = 0.22 nM