Brief Information of the Compound and Protein
Compound Name
 Compound Info 
3-benzenesulfonyl-8-piperazin-1-ylquinoline
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 PubChem ID
CID: 11256720
SID: 57304406
Canonical SMILES
O=S(=O)(c1ccccc1)c1cnc2c(cccc2c1)N1CCNCC1
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Compound Formula C19H19N3O2S
Compound Structure
Protein Name
 Protein Info 
5-hydroxytryptamine receptor 6
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Serotonin receptor
Uniprot ID
P50406
Gene Name
HTR6
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000047 108CC15
 Cell Line Info 
Mus musculus (Mouse)--NCBI_TaxID=10116;  2
1
IC50 = 2.8 nM
   TI
   LI
   LO
   TS
2
IC50 = 97 nM
   TI
   LI
   LO
   TS
CL000094 1321N1
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 2.8 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
Ki = 1.4 nM
   TI
   LI
   LO
   TS
CL000017 HeLa
 Cell Line Info 
Homo sapiens (Human)  1
1
Ki < 10 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 0.23 nM
2 Ki = 0.234 nM
3 Ki = 0.25 nM
4 Ki = 0.28 nM