Brief Information of the Compound and Protein
Compound Name
1-[4-[3-[[4-[3-(hydroxymethyl)anilino]-5-methylpyrimidin-2-yl]amino]-5-methylsulfonylphenyl]piperazin-1-yl]ethanone
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PubChem ID
CID: 145958260
Canonical SMILES
CC(=O)N1CCN(CC1)c1cc(Nc2ncc(C)c(Nc3cccc(CO)c3)n2)cc(c1)S(C)(=O)=O
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Compound Formula C25H30N6O4S
Compound Structure
Protein Name
Tyrosine-protein kinase JAK1
Protein Classification
Enzyme
>
Kinase
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Protein Kinase
>
TK protein kinase group
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Tyrosine protein kinase JakB family
Uniprot ID
P23458
Gene Name
JAK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000157 NCI-H1975 Homo sapiens (Human)  1
1
EC50 > 3000 nM
   TI
   LI
   LO
   TS