Brief Information of the Compound and Protein
Compound Name
2-N-[2-fluoro-5-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]pyridin-3-yl]-5-methyl-4-N-[(2R)-3-methylbutan-2-yl]pyrimidine-2,4-diamine
    Show/Hide
PubChem ID
CID: 145973587
Canonical SMILES
CC(C)[C@@H](C)Nc1nc(Nc2cc(cnc2F)N2C[C@@H]3C[C@H]2CN3C)ncc1C
    Show/Hide
Compound Formula C21H30FN7
Compound Structure
Protein Name
Tyrosine-protein kinase JAK1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase JakB family
Uniprot ID
P23458
Gene Name
JAK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000157 NCI-H1975 Homo sapiens (Human)  1
1
EC50 = 50 nM
   TI
   LI
   LO
   TS