Brief Information of the Compound and Protein
Compound Name
2-(3,4-dimethoxyphenyl)-N-(4-nitrophenyl)quinazolin-4-amine
    Show/Hide
PubChem ID
CID: 15999199
Canonical SMILES
COc1ccc(cc1OC)-c1nc(Nc2ccc(cc2)[N+]([O-])=O)c2ccccc2n1
    Show/Hide
Compound Formula C22H18N4O4
Compound Structure
Protein Name
Broad substrate specificity ATP-binding cassette transporter ABCG2
Protein Classification
Transporter
>
Primary active transporter
>
ATP-binding cassette
>
ABCG subfamily
Uniprot ID
Q9UNQ0
Gene Name
ABCG2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000036 MDCK-II Canis lupus familiaris (Dog)  4
1
EC50 = 7.4 nM
   TI
   LI
   LO
   TS
2
EC50 = 12.7 nM
   TI
   LI
   LO
   TS
3
IC50 = 300 nM
   TI
   LI
   LO
   TS
4
IC50 = 320 nM
   TI
   LI
   LO
   TS