Brief Information of the Compound and Protein
| Compound Name |
4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine
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PubChem ID | |||||
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Compound Structure |
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| Protein Name |
Serine/threonine-protein kinase mTOR
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Protein Classification |
Enzyme
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Kinase
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Protein Kinase
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Atypical protein kinase group
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Atypical protein kinase PIKK family
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Atypical protein kinase FRAP subfamily
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| Uniprot ID | Gene Name | MTOR |
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Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
| Cell Line ID | Cell Line Name | Cell Line Organism | |
| CL000012 | Sf21 | Spodoptera frugiperda (Fall armyworm) | 1 |
| 1 |
IC50 = 134 nM
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TI
LI
LO
TS
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Biochemical Assays
| 1 | IC50 = 3 nM | ||
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| 2 | IC50 = 310 nM | ||
| 3 | IC50 = 410 nM | ||
| 4 | IC50 = 580 nM | ||
| 5 | IC50 = 712 nM | ||
| 6 | IC50 = 959 nM | ||
| 7 | IC50 = 3351 nM | ||
| 8 | Kd = 48 nM | ||
| 9 | Kd = 200 nM | ||
| 10 | Ki = 570 nM | ||
| 11 | Ki = 580 nM | ||