Brief Information of the Compound and Protein
Compound Name
 Compound Info 
5-[(1S)-1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-2-[2-(oxan-4-ylamino)pyrimidin-4-yl]-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4-one
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 PubChem ID
CID: 137654819
Canonical SMILES
OC[C@@H](N1CCc2[nH]c(cc2C1=O)-c1ccnc(NC2CCOCC2)n1)c1ccc(F)c(Cl)c1
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Compound Formula C24H25ClFN5O3
Compound Structure
Protein Name
 Protein Info 
Mitogen-activated protein kinase 1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
CMGC protein kinase group
>
CMGC protein kinase MAPK family
>
CMGC protein kinase ERK subfamily
Uniprot ID
P28482
Gene Name
MAPK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000045 A-375
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 130 nM
   TI
   LI
   LO
   TS
2
IC50 = 3300 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 < 0.31 nM
2 IC50 = 0.72 nM