Brief Information of the Compound and Protein
Compound Name
2-[2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one
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PubChem ID
CID: 137348765
Canonical SMILES
CN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2cc3c(CCNC3=O)[nH]2)cc1
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Compound Formula C22H25N7O
Compound Structure
Protein Name
Mitogen-activated protein kinase 1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
CMGC protein kinase group
>
CMGC protein kinase MAPK family
>
CMGC protein kinase ERK subfamily
Uniprot ID
P28482
Gene Name
MAPK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000045 A-375 Homo sapiens (Human)  2
1
IC50 = 160 nM
   TI
   LI
   LO
   TS
2
IC50 = 570 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 36 nM
2 IC50 = 370 nM