Brief Information of the Compound and Protein
Compound Name
(6S)-5-(2-methoxyethyl)-6-methyl-2-[5-methyl-2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4-one
    Show/Hide
PubChem ID
CID: 126480564
Canonical SMILES
COCCN1[C@@H](C)Cc2[nH]c(cc2C1=O)-c1nc(Nc2ccnn2C)ncc1C
    Show/Hide
Compound Formula C20H25N7O2
Compound Structure
Protein Name
Mitogen-activated protein kinase 1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
CMGC protein kinase group
>
CMGC protein kinase MAPK family
>
CMGC protein kinase ERK subfamily
Uniprot ID
P28482
Gene Name
MAPK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000045 A-375 Homo sapiens (Human)  2
1
IC50 = 200 nM
   TI
   LI
   LO
   TS
2
IC50 = 8100 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 < 0.3 nM