Brief Information of the Compound and Protein
Compound Name
 Compound Info 
SCH772984
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 PubChem ID
CID: 24866313
SID: 50099060
Canonical SMILES
O=C(CN1CC[C@@H](C1)C(=O)Nc1ccc2[nH]nc(-c3ccncc3)c2c1)N1CCN(CC1)c1ccc(cc1)-c1ncccn1
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Compound Formula C33H33N9O2
Compound Structure
Protein Name
 Protein Info 
Mitogen-activated protein kinase 1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
CMGC protein kinase group
>
CMGC protein kinase MAPK family
>
CMGC protein kinase ERK subfamily
Uniprot ID
P28482
Gene Name
MAPK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000045 A-375
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 4 nM
   TI
   LI
   LO
   TS
2
IC50 = 20 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 < 0.3 nM
2 IC50 = 0.4 nM
3 IC50 = 1 nM
4 Kd = 0.05012 nM
5 Kd = 0.1 nM