Brief Information of the Compound and Protein
Compound Name
N-(4-methoxyphenyl)-2-phenylpyrido[2,3-d]pyrimidin-4-amine
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PubChem ID
CID: 137650017
Canonical SMILES
COc1ccc(Nc2nc(nc3ncccc23)-c2ccccc2)cc1
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Compound Formula C20H16N4O
Compound Structure
Protein Name
Broad substrate specificity ATP-binding cassette transporter ABCG2
Protein Classification
Transporter
>
Primary active transporter
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ATP-binding cassette
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ABCG subfamily
Uniprot ID
Q9UNQ0
Gene Name
ABCG2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000036 MDCK-II Canis lupus familiaris (Dog)  3
1
EC50 = 29.4 nM
   TI
   LI
   LO
   TS
2
GI50 = 20.9 nM
   TI
   LI
   LO
   TS
3
IC50 = 238 nM
   TI
   LI
   LO
   TS