Brief Information of the Compound and Protein
Compound Name
N,2-diphenylpyrido[2,3-d]pyrimidin-4-amine
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PubChem ID
CID: 137639918
Canonical SMILES
N(c1ccccc1)c1nc(nc2ncccc12)-c1ccccc1
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Compound Formula C19H14N4
Compound Structure
Protein Name
Broad substrate specificity ATP-binding cassette transporter ABCG2
Protein Classification
Transporter
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Primary active transporter
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ATP-binding cassette
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ABCG subfamily
Uniprot ID
Q9UNQ0
Gene Name
ABCG2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000036 MDCK-II Canis lupus familiaris (Dog)  3
1
EC50 = 37.1 nM
   TI
   LI
   LO
   TS
2
GI50 = 8.61 nM
   TI
   LI
   LO
   TS
3
IC50 = 149 nM
   TI
   LI
   LO
   TS