Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

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PubChem ID

CID: 5265

SID: 14903329

Canonical SMILES	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)N(CNC2=O)c1ccccc1 Show/Hide
Compound Formula	C23H26FN3O2

Compound Structure

Protein Name

Protein Info

D(2) dopamine receptor

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Monoamine receptor

Dopamine receptor

Uniprot ID

P14416

Gene Name

DRD2

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	3
1	EC50 = 1.4 nM	TI LI LO TS
2	IC50 = 0.25 nM	TI LI LO TS
3	Ki = 0.089 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	8
1	IC50 = 1.27 nM	TI LI LO TS
2	IC50 = 2.56 nM	TI LI LO TS
3	Ki = 0.06 nM	TI LI LO TS
4	Ki = 0.28 nM	TI LI LO TS
5	Ki = 0.44 nM	TI LI LO TS
6	Ki = 0.5 nM	TI LI LO TS
7	Ki = 1.08 nM	TI LI LO TS
8	Ki = 1.2 nM	TI LI LO TS

Biochemical Assays