Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-isoquinolin-6-yl-3-[2-oxo-2-(3,3,4,4-tetrafluoropyrrolidin-1-yl)ethyl]urea
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 PubChem ID
CID: 137636442
Canonical SMILES
FC1(F)CN(CC1(F)F)C(=O)CNC(=O)Nc1ccc2cnccc2c1
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Compound Formula C16H14F4N4O2
Compound Structure
Protein Name
 Protein Info 
Protein arginine N-methyltransferase 3
Protein Classification
Epigenetic regulator
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Writer
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Protein methyltransferase
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Protein arginine methyltransferase
Uniprot ID
O60678
Gene Name
PRMT3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 2700 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 = 3100 nM
   TI
   LI
   LO
   TS
2
IC50 = 240 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 24 nM