Brief Information of the Compound and Protein
Compound Name
(2R)-N-(3-(2-(1,3-dimethyl-1H-pyrazol-4-ylamino)-5-fluoropyrimidin-4-yl)-1H-indol-7-yl)-2-(4-methylpiperazin-1-yl)butanamide
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PubChem ID
CID: 126715362
Canonical SMILES
CC[C@H](C(=O)Nc1cccc2c(-c3nc(Nc4cn(C)nc4C)ncc3F)c[nH]c12)N1CCN(C)CC1
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Compound Formula C26H32FN9O
Compound Structure
Protein Name
Tyrosine-protein kinase JAK1
Protein Classification
Enzyme
>
Kinase
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Protein Kinase
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TK protein kinase group
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Tyrosine protein kinase JakB family
Uniprot ID
P23458
Gene Name
JAK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000157 NCI-H1975 Homo sapiens (Human)  1
1
IC50 = 75.1 nM
   TI
   LI
   LO
   TS