Brief Information of the Compound and Protein
Compound Name
(E)-3-[4-(1-cyclopropylpyrazol-4-yl)pyridin-3-yl]-N-[4-(2-oxa-5-azabicyclo[2.2.1]heptan-5-ylmethyl)phenyl]prop-2-enamide
    Show/Hide
PubChem ID
CID: 126568668
Canonical SMILES
O=C(Nc1ccc(CN2CC3CC2CO3)cc1)\C=C\c1cnccc1-c1cnn(c1)C1CC1
    Show/Hide
Compound Formula C26H27N5O2
Compound Structure
Protein Name
Cyclin-dependent kinase 8
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
CMGC protein kinase group
>
CMGC protein kinase CDK family
>
CMGC protein kinase CDK8 subfamily
Uniprot ID
P49336
Gene Name
CDK8
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000015 SW480 Homo sapiens (Human)  1
1
EC50 = 3.1 nM
   TI
   LI
   LO
   TS