Brief Information of the Compound and Protein
Compound Name
(E)-3-[4-(1-methylpyrazol-4-yl)pyridin-3-yl]-N-[2-(2,2,2-trifluoroethyl)-3,4-dihydro-1H-isoquinolin-7-yl]prop-2-enamide
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PubChem ID
CID: 126568395
Canonical SMILES
Cn1cc(cn1)-c1ccncc1\C=C\C(=O)Nc1ccc2CCN(CC(F)(F)F)Cc2c1
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Compound Formula C23H22F3N5O
Compound Structure
Protein Name
Cyclin-dependent kinase 8
Protein Classification
Enzyme
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Kinase
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Protein Kinase
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CMGC protein kinase group
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CMGC protein kinase CDK family
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CMGC protein kinase CDK8 subfamily
Uniprot ID
P49336
Gene Name
CDK8
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000015 SW480 Homo sapiens (Human)  1
1
EC50 = 8.4 nM
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